陈实，二级教授，深圳市转化医学研究院院长，深圳大学第一附属医院、深圳市第二人民医院特聘教授。

入选美国微生物科学院院士，主持国家基金委杰出青年基金、重点国际合作项目、面上项目等，任科技部重点专项首席科学家。致力于医学微生物、化学生物学、精准医学、合成生物学与药物发现方面的研究。

以通讯或共同通讯作者在Nature Catalysis，PNAS (3篇), Nature Communications（4篇）, Advanced Materials、Advanced Science（2篇）、Angew Chem Int Ed, Autophagy, Clinical Microbiology Reviews, FEMS Microbiology Reviews, Trends in Cell Biology, Biotechnology Advances, Medicinal Research Reviews, Molecular Neurodegeneration, Theranostics (2篇)，Protein & Cell，Cell Death & Disease，mBio（4篇）, Analytical Chemistry等发表论文。

任国际化学生物学协会国际委员会成员，曾任中国遗传学会微生物遗传专业委员会副主任委员、Microbiological Research和BMC Systems Biology副主编，现任mLife、Engineering Microbiology等编委。

硕士毕业于华中农业大学生物技术本硕连读班，博士毕业于上海交通大学；

博士期间赴韩国高等科技学院进行合作交流。

先后在美国麻省理工学院进行博士后研究、哈佛大学进行研究工作、武汉大学药学院任教。

1.基因组修饰编辑与合成生物学

利用最新发展的合成生物学前沿技术，对细胞或病原菌基因组进行精确地鉴定、修饰和编辑，鉴定宿主对病毒或病原菌的防御机制，结合表观遗传学、基因组学、蛋白组学等，发展出特定设计的工程细胞，解析这些表观遗传学修饰或基因组改造对细胞生命活动或对病原菌侵染能力的影响，并阐明这些修饰或改造对超级耐药菌的作用。

2.创新药物的设计与改造

依据药物合成的机理及对病毒、神经、肿瘤等重大疾病致病机理的认识，通过全面的病理分析，合理筛选并设计潜在药物，并通过前沿技术合成生物学、基因组编辑、基因工程、蛋白质工程、代谢工程及组合生物合成途径进行优化改造，发展相应的创新药物、mRNA疫苗和治疗手段，以获得性能改善并可应用于临床的创新药物。

1.Dan Wu, Yaqian Tang, Siwei Chen, Yue He, Xiaofei Chang, Wenzhong Zheng, Zixin Deng, Zhiqiang Li, Lianrong Wang*, Geng Wu*, Shi Chen*. The functional coupling between restriction and DNA phosphorothioate modification systems underlying the DndFGH restriction complex. Nature Catalysis. 2022, December, 5, 1131–1144.

2.Chao Chen^#, Lianrong Wang^#, Si Chen, Xiaolin Wu, Meijia Gu, Xi Chen, Susu Jiang, Yunfu Wang Zixin Deng, Peter C. Dedon, Shi Chen*. Convergence of DNA methylation and phosphorothioation epigenetics in bacterial genomes. Proc Natl Acad Sci U S A, 2017, 114(17): 4501–4506. doi: 10.1073/pnas.1702450114.

3.Lei Xiong^#, Siyi Liu^#, Si Chen^#, Yao Xiao^#, Bochen Zhu, Yali Gao, Yujing  Zhang, Beibei Chen, Jie Luo, Zixin Deng, Xiangdong Chen, Lianrong Wang, Shi Chen*. A new type of DNA phosphorothioation-based antiviral 1 system in archaea. Nature Communications,2019, 10:1688 | https://doi.org/10.1038/s41467-019-09390-9.

4.Tong Tong^#, Si Chen#, Lianrong Wang^#, You Tang^#, Jae Yong Ryu, Susu Jiang, Xiaolin Wu, Chao Chen, Jie Luo, Zixin Deng, Zhiqiang Li, Sang Yup Lee*, Shi Chen*. Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria, Proc Natl Acad Sci U S A, 2018,115(13):2988-2996. doi:10.1073/pnas.1721916115.

5.Haiyan Gao^#, Xinqi Gong^#, Jinchuan Zhou, Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen*, Geng Wu *, Lianrong Wang*. Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE. Nature Communications, 2022, November, 13:6773.

6.Ming-Yu Wu^#, Luojia Chen^#, Qingrong Chen, Rui Hu, Xiaoyu Xu, Yifei Wang, Jie Li, Shun Feng, Changjiang Dong, Xiao-Lian Zhang, Zhiqiang Li,Lianrong Wang*, Shi Chen*, Meijia Gu*. Engineered Phage with Aggregation-Induced Emission Photosensitizer in Cocktail Therapy against Sepsis. Advanced Materials. 2023, 35, 2208578, DOI: 10.1002/adma.202208578.

7.Xuan Zou, Xiaohong Xiao, Ziran Mo, Yashi Ge, Xing Jiang, Ruolin Huang, Mengxue Li, Zixin Deng, Shi Chen*, Lianrong Wang*, Sang Yup Lee*. Systematic strategies for developing phage resistant Escherichia coli strains. Nature Communications, 2022, 13: 4491.

8.Ming-Yu Wu^#, Xiaoyu Xu^#, Rui Hu^#, Qingrong Chen, Luojia Chen, Yuncong Yuan, Jie Li, Li Zhou, Shun Feng,Lianrong Wang*, Shi Chen*, Meijia Gu*. A membrane-targeted photosensitizer prevents drug resistance and induces immune response in treating Candidiasis. Advanced Science. 2023; e2207736. DOI: 10.1002/advs.202207736.

9.Bo Cao^#, Chao Chen^#, Michael S. DeMott^#, Qiuxiang Cheng, Tyson A. Clark, Xiaolin Xiong, Xiaoqing Zheng, Vincent Butty, Stuart S. Levine, George Yuan, Matthew Boitano, Khai Luong, Yi Song, Xiufen Zhou, Zixin Deng, Stephen W. Turner, Jonas Korlach, Delin You*, Lianrong Wang*, Shi Chen*, Peter C. Dedon. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications, 2014, 5, doi:10.1038/ncomms4951.

10.Lianrong Wang, Susu Jiang, Chao Chen, Wei He, Xiaolin Wu, Fei Wang, Tong Tong, Xuan Zou, Zhiqiang Li, Jie Luo, Zixin Deng, Shi Chen*. Synthetic genomes: from DNA synthesis to genome design. Angew Chem Int Ed., 2018, 57: 2~11.

11.Meijia Gu^#, Xiaoyu Xu^#, Ming-Yu Wu^#, Chao Chen, Yuncong Yuan, Qingrong Chen, Yidan Sun, Luojia Chen, Chao Shen, Peng Guo, Shujie Liu, Engui Zhao*, Shi Chen*, Sijie Chen*. Simultaneous photodynamic eradication of tooth biofilm and tooth whitening with an aggregation-induced emission luminogen. Advanced Science, 2022, 9, 2106071.

12.Yanlian Chen, Zhiqiang Deng, Shuai Jiang, Qian Hu, Haiying Liu, Zhou Songyang, Wenbin Ma, Shi Chen*, Yong Zhao*. Human cells lacking coilin and Cajal bodies are proficient in telomerase assembly, trafficking and telomere maintenance. Nucleic Acids Research, 2014, 1-11, doi: 10.1093/nar/gku1277.

13.Lianrong Wang, Shi Chen*, Kevin L. Vergin, Stephen J. Giovannoni, Simon W. Chan, Michael S. DeMott, Koli Taghizadehe, Otto X. Cordero, Michael Cutler, Sonia Timberlake, Eric J. Alm, Martin F. Polz, Jarone Pinhassi, Zixin Deng, Peter C. Dedon*. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proc Natl Acad Sci U S A, 2011, 108 (7): 2963-2968.

14.Wenzhong Zheng^#, Kexin Wang^#,Yachen Wu^#, Ge Yan, Chi Zhang, Zhiqiang Li, Lianrong Wang*, Shi Chen*.C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α. Theranostics, 2022, Oct 17;12(17):7289-7306. doi: 10.7150/thno.76138.

15.Zhiqiang Deng, Junghyun Lim, Qian Wang, Kerry Purtell, Shuai Wu, Gloria M. Palomo, Haiyan Tan, Giovanni Manfredi, Yanxiang Zhao, Junmin Peng, Bo Hu, Shi Chen*, Zhenyu Yue*. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/ NRF2 anti-oxidative stress pathway. Autophagy, 2019. DOI: 10.1080/15548627.2019.1644076.

16.Fang Wang, Runhua Han, Shi Chen*. An overlooked and underrated endemic mycosis—Talaromycosis and the pathogenic fungus Talaromyces marneffei. Clinical Microbiology Reviews, 2023 23;36(1):e0005122.

17.Yajie Wang^#, Zhikang Mia^o#, Chang Xu, Ying Cai, Yuting Yang, Yue Hu, Mengna Zhao, Yue Shao, Zhiqiang Li, Jincao Chen, Shi Chen*, Lianrong Wang*. Pathological convergence of APP and SNCA deficiency in hippocampal degeneration of young rats. Cell Death & Disease, 2023 May 13;14(5):325. DOI: 10.1038/s41419-023-05846-5.

18.Huang Q, Wang F, Yuan C, He Z, Rao L, Cai B, Chen B, Jiang S, Li Z, Chen J, Liu W, Guo F, Ao Z*, Shi Chen*, Zhao X*. Gelatin nanoparticle-coated silicon beads for density-selective capture and release of heterogeneous circulating tumor cells with high purity. Theranostics, 2018, 8(6): 1624~1635.

19.Deng Z, Purtell K Lachance V, Wold M, Shi Chen*, Yue Z*. Autophagy Receptors and Neurodegenerative Diseases. Trends in Cell Biology, 2017, 27(7).491~504. doi.org/10.1016/j.tcb.2017.01.001.

20.Fei Wang^#, Lianrong Wang^#, Xuan Zou, Suling Duan, Zhiqiang Li, Zixin Deng, Jie Luo, Sang Yup Lee*, Shi Chen*. Advances in CRISPR-Cas systems for RNA targeting, tracking and editing. Biotechnology Advances. 2019 Mar 27. pii: S0734-9750(19)30052-7. doi: 10.1016/j.biotechadv.2019.03.016.

21.Lianrong Wang, Susu Jiang, Zixin Deng, Peter Dedon, Shi Chen*. DNA phosphorothioate modification–a new multi-functional epigenetic system in bacteria. FEMS Microbiology Reviews. 2019, 43(2), 109–122. https://doi.org/10.1093/femsre/fuy036.

22.Meijia Gu^#*, Luojia Chen^#, Rui Hu, Qingrong Chen, Jianbo Liu*, Lianrong Wang*, Shi Chen*. Aggregation-induced emission: recent applications in infectious diseases. SCIENCE CHINA Chemistry, 2023 Oct 24. doi.org/10.1007/s11426-023-1825-7.

23.Zhiqiang Deng, Patricia Sheehan, Shi Chen*, Zhenyu Yue*. Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease? Molecular Neurodegeneration (2017) 12:90. DOI 10.1186/s13024-017-0232-6.

24.Xuan Zou^#, Lianrong Wang^#, Zhiqiang Li, Jie Luo, Yunfu Wang, Zixin Deng, Shiming Du, Shi Chen*. Genome engineering and modification toward synthetic biology for the production of antibiotics. Medicinal Research Reviews, 2018, 38(1): 229~260.

25.Shi Chen*, Lianrong Wang, Zixin Deng*. Twenty years hunting for sulfur in DNA. Protein & Cell, 2010, 1(1): 14-21.

热情欢迎坚韧、进取、有理想、勤奋的硕博学生一起共同探索。

高薪诚聘结构生物学、mRNA疫苗、生物信息学、表观遗传学、微生物学、纳米生物材料、细胞生物学、生物化学与分子生物学、神经生物学、免疫学、创新药物的设计与改造方向博士后6名。

2022年  科技部重点专项首席科学家

2020年  美国微生物科学院院士 (Fellow of American Academy of Microbiology)

2019年  国家基金委杰出青年基金

2018年  科技部中青年科技创新领军人才

2017年  湖北省医学领军人才

2016年  中国微生物学会学术年会优秀学术论文奖

2015年  高等学校科学研究优秀成果奖自然科学一等奖（6）

2014年  中国微生物学会学术年会优秀学术论文奖

2013年  湖北省特聘专家

2012年  湖北省楚天学者特聘教授

2008年  国家自然科学奖二等奖（5）

2008年  新加坡陈嘉庚基金会第六届陈嘉庚青少年发明奖（上海）（铜奖）

2007年《环球科学》2007年度全球十大科学新闻

2007年  上海市优秀发明奖选拔赛二等奖

2007年  新加坡陈嘉庚基金会第五届陈嘉庚青少年发明奖（上海）（铜奖）

2006年  上海市研究生学位论文优秀成果

2004年  上海市科技进步一等奖（4）

2004年  上海市新长征突击手“标兵”

2004年  新加坡陈嘉庚基金会第二届陈嘉庚青少年发明奖（上海）（银奖）

2004年  明治乳业生命科学优秀奖

2004年  上海-联合利华研究与发展基金奖学金